Abstract Search

ea0029oc9.3 | Endocrine Tumours & Translation | ICEECE2012

The central role of estrogen receptor α in IGF2 dependent adrenocortical carcinoma (ACC) cell proliferation suggests the use of selective estrogen receptor modulators (SERMs) for the treatment of ACC

Sirianni R. , Chimento A. , De Luca A. , Cerquetti L. , Carpinelli G. , Fallo F. , Pilon C. , Arnaldi G. , Stigliano A. , Pezzi V.

Adrenocortical Cancer (ACC) is characterized by an increased production of insulin-like growth factor 2 (IGF2) and by estrogen receptor (ER) α up-regulation. Aim of this study was to define IGF2 and estrogen signaling interactions in ACC, in order to give new indications for a better therapy. To this aim we used H295R cells and human ACC tissues which display common features: IGF2 activation of downstream effector pathways and over-expression of estrogen-related genes inc...

0 shares

Endocrine Abstracts

The central role of estrogen receptor α in IGF2 dependent adrenocortical carcinoma (ACC) cell proliferation suggests the use of selective estrogen receptor modulators (SERMs) for the treatment of ACC

BiosciAbstracts